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Dr Katrina Lythgoe

Dr Katrina Lythgoe

Evolutionary Dynamics of Human Diseases
Dr Katrina Lythgoe is a Wellcome Trust Research Fellow at the Infectious Disease Epidemiology Department at Imperial College London.
Dr Lythgoe was awarded a Fellowship to continue her work in multiscale evolutionary dynamics to help combat the spread of infectious diseases (such as malaria and HIV). Her work will try to understand how pathogens are likely to evolve under different intervention strategies before they are widely implemented with the use of appropriate mathematical models. Because pathogens are typically subject to conflicting selection pressures it is important to simultaneously model the selection within individuals and at transmission. Although many pathogen strains are typically present in an infected individual, existing models do not account for this, even though this is likely to have a dramatic impact on predictions. The aim is to develop a modelling framework that concurrently follows up to 100 strains during each infection together with transmission at the population level which will be applied to HIV and malaria while also informing the design of intervention strategies for these diseases. Dr Lythgoe plans to spend the fellowship on an important international research trip as well as travel and childcare costs.

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